ADRENOTROPHIC ACTIVITY OF HUMAN BLOOD1

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Abstract
To avoid as far as possible the usual pitfalls encountered in studies of pituitary-adrenal relationships, the authors investigated the problem of detection and assay of adrenotrophic hormone in human blood with the use of a sensitive and specific assay method so as to avoid spurious results, the use of fresh untreated serum so as to obviate the use of empirical methods of concentration and purification, and the use of blood from patients with adrenal disorders, situations in which extreme ranges of adrenotrophin might conceivably be encountered. Adrenotrophic activity was demonstrated in the blood of patients with adrenal cortical insufficiency. Conclusive demonstration of adrenotrophic activity in the blood of normal subjects and of patients with adrenal cortical hyperfunction was not achieved.

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