IV. CONTRIBUTIONS TO THE PHYSIOLOGY OF THE PANCREAS

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Abstract
Of 90 dyes injected intravenously into animals with permanent pancreatic fistulae, 10 were eliminated in the pancreatic secretion. They are acid fuchsin, basic fuchsin, fast yellow, flourescein, methyl orange, methylene blue, para-fuchsin, rhodamin B, safranin O, and safranin extra bluish. All of these are crystalloids, but many crystalloids of low molecular weight were not eliminated. The excreted dyes differ from each other markedly in chemical and physical properties; no explanation could be found for the elimination of these dyes and the retention of others. The dyes which are eliminated appear in the pancreatic juice in concentrations very much lower than their probable concentration in the body fluids. Sodium thiocyanate was eliminated, Nal and pyridium were not.

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