Two-dimensional electrophoresis of plasma polypeptides reveals "high" heterozygosity indices.
- 1 August 1983
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 80 (16) , 5002-5006
- https://doi.org/10.1073/pnas.80.16.5002
Abstract
A series of 62 plasma samples were examined for genetic variation by the technique of 2-dimensional polyacrylamide gel electrophoresis followed by silver-staining of the gels. Polypeptides (20) chosen without respect to variability were considered suitable for scoring. Of the total of 1240 polypeptides, 29 could not be scored unambiguously. Of the remaining 1211, 75 exhibited the combination of a normal and a variant polypeptide. All variants were present in either the father or the mother of the subject. This index of heterozygosity (6.2 .+-. 0.7%) is substantially higher than those reported by others in similar studies of human fibroblasts, lymphocytes, kidney or brain cells.This publication has 24 references indexed in Scilit:
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