Eurotium (Aspergillus) repens metabolites and their biological activity
- 1 November 1978
- journal article
- research article
- Published by Springer Nature in Folia Microbiologica
- Vol. 23 (6) , 438-443
- https://doi.org/10.1007/bf02885572
Abstract
Eurotium repens mycelium cultivated under static conditions was used to isolate and identify metabolities—echinulin, physcion, erythroglaucin, flavoglaucin and asperentin; the filtrate of the culture yielded asperentin 8-methylether. The broadest biological activity spectrum was displayed by asperentin which had antibacterial and antifungal effects and, at a concentration of 86 ώg/ml, caused 50 % mor7 tality inArtemia saline larvae. The highest cytotoxicity towards HeLa cells was found in physcion which caused 50 % growth inhibition at a concentration of 0.1 ώg/ml.Keywords
This publication has 20 references indexed in Scilit:
- Toxicity of Mycotoxins and Other Fungal Metabolites to Artemia Salina LarvaeZentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite Naturwissenschaftliche Abteilung: Allgemeine, Landwirtschaftliche und Technische Mikrobiologie, 1977
- Pattern of incorporation of leucine samples asymmetrically labelled with 13C in the isopropyl unit into the C5-isoprenoid units of echinuline and flavoglaucineJournal of the Chemical Society, Chemical Communications, 1977
- Molecular structure of cryptoechinuline a, a new metabolite of aspergillus amstelodami, isolated during investigations on echinuline biosynthesisTetrahedron Letters, 1974
- New metabolites of Aspergillus amstelodami related to the biogenesis of neoechinulinJournal of the Chemical Society, Chemical Communications, 1974
- New metabolic products of Aspergillus flavus. Part IV. 4′-Hydroxyasperentin and 5′-hydroxyasperentin 8-methyl etherJournal of the Chemical Society, Perkin Transactions 1, 1973
- New metabolic products of Aspergillus flavus. Part I. Asperentin, its methyl ethers, and 5′-hydroxyasperentinJournal of the Chemical Society, Perkin Transactions 1, 1972
- CLADOSPORIN, A NEW ANTIFUNGAL METABOLITE FROM CLADOSPORIUM ClADOSPORIOIDESThe Journal of Antibiotics, 1971
- Bestimmung der stellung von O-substituenten bei 1,8-dihydroxy-anthrachinon-derivaten mit hilfe der NMR-spektroskopieTetrahedron, 1969
- 600. Studies in relation to biosynthesis. Part XXIV. Some remarks on the structure of echinulinJournal of the Chemical Society, 1961
- Structure of Flavoglaucin and AuroglaucinNature, 1949