GRANULOCYTE MODULATION OF ENDOTOXIN-STIMULATED COLONY-STIMULATING ACTIVITY (CSA) PRODUCTION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (5) , 879-887
Abstract
Incubation of human macrophages with [Salmonella typhosa] endotoxin resulted in significantly enhanced CSA production by these cells. Preincubation of endotoxin with mature granulocytes abolished this stimulatory effect. The stimulatory effect of endotoxin on macrophage CSA production was not abolished by preincubation with NaF-treated granulocytes, granulocyte membranes or nonphagocytic cells (lymphocytes or erythrocytes). Mature granulocytes may play a role in the modulation of CSA production and granulopoiesis by inactivation of stimulatory materials such as endotoxin.