Preparation of Nucleoside Phosphorothioates, Phosphorodithioates and Related Compounds
- 1 December 1991
- journal article
- research article
- Published by Taylor & Francis in Sulfur reports
- Vol. 11 (1) , 167-188
- https://doi.org/10.1080/01961779108048765
Abstract
This review describes synthetic pathways to mono-, di- and oligonucleotides modified in the phosphate group(s) by substitution of one or several oxygen atoms with sulfur. The known sulfur-modified phosphate groups are nucleoside 3′- and 5′-O-phosphorothioates, nucleoside thiodi- and triphosphates, nucleoside cyclic phosphorothioates, di- and oligonucleoside O,O-phosphorothioates, nucleoside 3′-S-phosphorothioates, nucleoside and oligonucleoside 5′-S-phosphorothioates, nucleoside O-phosphorodithioates, di- and oligonucleoside O,O-phosphorodithioates, di- and oligonucleoside O,S-phosphorodithioates, thiophosphortriesters, thiophosphoramidates, and methylphosphonothioates.Keywords
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