Determination of residual blood volume required for survival in rapidly hemorrhaged splenectomized dogs

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Abstract
Twenty-four splenectomized dogs (average blood volume of 83 ml/kg) were hemorrhaged from 43–55% of their control blood volumes. The Fcells factor as determined from cell (Cr51) and plasma (T-1824) volume measurements was unchanged by severe hemorrhage. (0.88, S.D., 0.020 before and 0.88, S.D., 0.028 after hemorrhage). There were 12 survivors and 12 nonsurvivors. Fifty per cent survival occurred at a residual blood volume of 61%. The results are compared with previous studies in this laboratory and discussed in relation to factors that appear to influence the tolerance to reduction in blood volume.