Effect of Transplantation of Antrum of Stomach on Gastric Secretion in Experimental Animals

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Abstract
The effects were detn. of transplantation of the pyloric antrum of dogs to the abdominal wall, the duodenum, or the colon on gastric secretion by the fundus of the stomach. The gastric secretion from the vagotomized complete stomach pouch of the dog was increased from 8-30-fold by transplanting the antrum into the duodenum. This stimulation persisted after all nervous connections between the antrum and the fundus and body of the stomach had been severed. The effect of the antrum in this connection is specific, since body and fundic mucosa similarly transplanted from the stomach pouch into the duodenum produced no stimulation of gastric secretion. Transplantation of the antrum of the stomach into the colon as a diverticulum produced a long continued hypersecretion of gastric juice in Pavlov pouch dogs and in animals with complete stomach pouches. This excessive secretion persisted after division of all nervous and vascular connections to the antrum. The hypersecretion induced in dogs with vagotomized isolated stomachs by transplantation of the antrum into the colon regularly produced ulcers in the stomach of these animals and caused a progressive dehydration, hypochloremia, and alkalosis. Apparently the antrum of the stomach is a gland of internal secretion which produces a specific excitant of gastric secretion when it comes into contact with the usual content of the stomach, duodenum, or colon after feeding. It is probably the sole source of this substance and is responsible for the gastric, or hormonal, phase of secretion.

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