RECOVERY FROM X-RAY IRRADIATION INJURY DURING DELAYED IMPLANTATION IN THE RAT

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Abstract
SUMMARY: Whole body X-ray irradiation was administered to rats during experimentally delayed implantation. The effects of a short (1-day) and a long (9-day) interval between irradiation and the induction of implantation were studied. When one day intervened between irradiation and the induction of implantation, foetal survival decreased with each increase in dose (200–500 r.) and the weights of surviving foetuses were significantly lower than those of the non-irradiated controls. Foetal survival in rats with a 9-day interval between irradiation and the induction of implantation was not significantly different from that of the controls. Foetal weight was lower than that of non-irradiated controls but greater than that of rats with only a 1-day interval. It is concluded that the 9-day interval between irradiation and the induction of implantation allows time for repair of irradiation injury.