DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage
Open Access
- 1 April 2004
- journal article
- Published by Elsevier
- Vol. 279 (15) , 15269-15273
- https://doi.org/10.1074/jbc.m309917200
Abstract
No abstract availableKeywords
This publication has 23 references indexed in Scilit:
- Questioning the Role of Checkpoint Kinase 2 in the p53 DNA Damage ResponsePublished by Elsevier ,2003
- The Chk2 Tumor Suppressor Is Not Required for p53 Responses in Human Cancer CellsPublished by Elsevier ,2003
- Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent MannerMolecular and Cellular Biology, 2002
- Phosphorylation of Threonine 68 Promotes Oligomerization and Autophosphorylation of the Chk2 Protein Kinase via the Forkhead-associated DomainJournal of Biological Chemistry, 2002
- Functional impact of concomitant versus alternative defects in the Chk2-p53 tumour suppressor pathwayOncogene, 2001
- DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2Science, 2000
- Atm selectively regulates distinct p53-dependent cell-cycle checkpoint and apoptotic pathwaysNature Genetics, 1997
- Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell LineScience, 1995
- p53-Dependent apoptosis suppresses tumor growth and progression in vivoCell, 1994
- A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasiaCell, 1992