The Effect of Isoniazid and Para-Aminosalicylic Acid on Infection in Mice Produced byMycobacterium Kansasii1,2
- 1 January 1965
- journal article
- research article
- Published by American Thoracic Society in American Review of Respiratory Disease
- Vol. 91 (1) , 21-29
- https://doi.org/10.1164/arrd.1965.91.1.21
Abstract
Despite susceptibility in-vitro, para-aminosalicylic (PAS) acid did not inhibit growth of strain-A of M. kansasii in-vivo. The infective processes was enhanced by the administration of PAS to the animals. The maintenance in the block of a concentration of 0.6-2.4 of microbiologically active isoniazid/ml (0.05% in diet) suppressed growth of strain-A and destroyed the injected organisms. Streptomycin exerted a definite, but limited, chemotherapeutic effect.Keywords
This publication has 1 reference indexed in Scilit:
- Determination of Para-Aminosalicylic Acid in Blood.Experimental Biology and Medicine, 1948