Excretion and Distribution of Polyvinyl Pyrrolidone in Man: As Determined by Use of Radiocarbon as a Tracer

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Abstract
The excretion and distribution of the plasma extender, polyvinyl pyrrolidone (PVP), was studied in 4 patients, using C14-labeled PVP-macrose as a tracer. About 1/3 was excreted in the urine in the first 6 hrs. and 2/3 in the first 24 hrs. Small amts. were excreted in the feces. The unexcreted portion showed a distribution consistent with that of any inert material of large molecular size, with kidneys, lungs, liver, spleen and lymph nodes tending to show the greatest concn. No histologic evidence of PVP itself, or damage caused by it, was demonstrated. Nothing can be concluded from these data about the effectiveness of PVP-macrose as a plasma extender or about possible physiologic damage resulting from its use.

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