Effect of Polyvinylpyrrolidone on Reticulo-Endothelial Storage

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Abstract
Subcut. injns. of 3.5% solns. of Pplyvinylpyrrolidone (PVP) were given to mice of strains C57 Black, C3H, dba and CBA. After 12 to 24 injns. histologic evidence of storage of PVP was found in reticulo-endothelial cells of liver, spleen and lymph nodes. C57 Black mice required a larger number of injns. than C3H mice before storage became manifest. Simultaneous admn. of PVP and the sulfonated azo dye Erie Fast Rubine resulted in appearance of dye in serum and urine, which was not the case in controls injected with dye in saline, and r.e. storage of dye was decreased in PVP-injected animals. Injn. of PVP after admn. of dye brought about partial elution of stored dye, as shown by coloration of serum and urine and by histologic examination. Admn. of PVP prior to admn. of dye (Chlorazol Black E) prevented storage of dye almost completely. These observations indicate that evaluation of biologic properties of PVP must include its effect on reticulo-endothelial activity.