Optimizing the Friability of a Tablet Formulation
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 13 (6) , 1063-1067
- https://doi.org/10.3109/03639048709068370
Abstract
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.This publication has 1 reference indexed in Scilit:
- Optimization of Disintegration Time and Crushing Strength of a Tablet FormulationDrug Development and Industrial Pharmacy, 1985