AN INHIBITORY EFFECT OF ATROPINE ON RESPONSES OF THE VAS DEFERENS OF THE MOUSE TO FIELD STIMULATION
Open Access
- 19 July 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 54 (3) , 339-349
- https://doi.org/10.1111/j.1476-5381.1975.tb07574.x
Abstract
1 Atropine is shown to impair responses of the vas deferens of the mouse to field stimulation by acting at a site proximal to the smooth muscle cells. 2 The inhibitory effect of atropine is prevented by desmethylimipramine and reversed by dexamphetamine, and appears similar to the adrenergic-neurone blockade of guanethidine. 3 Electronmicroscopical studies show the presence in vas of presumptive noradrenergic axons which have acetylcholinesterase reaction product associated with their axolemmae. 4 These results are discussed in relation to the controversial hypothesis of a ‘cholinergic link’ in noradrenergic transmission.Keywords
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