EFFECTS OF LUTEOTROPIC DOSES OF CHORIONIC GONADOTROPIN IN WOMEN*

Publisher Website
Google Scholar
Abstract
Six women with regular menstrual cycles have been treated with 10,000 i.u. daily of chorionic gonadotropin. Delay in the onset of the next menstrual period occurred in all and was accompanied by a decidual change in the endometrium. In all 6 patients large amounts of chorionic gonadotropin appeared in the urine. Urinary 17-ketosteroid and glycogenic corticoid excretion were variable, showing both increases and decreases. In the 5 patients in whom urinary prolactin excretions were obtained, there was an increase. In none of the patients did anti-hormones for chorionic gonadotropin develop. Other morphologic observations included the occurrence of unusually hyperplastic secretory glands of the endometrium in 2 instances; a decidual reaction of the ovary in 1, and a decidual reaction in an endometrial cyst of the ovary in another. One patient had two active corpora lutea present in one ovary.

This publication has 5 references indexed in Scilit: