Role of ribosomes in streptomycin-activated suppression.
Open Access
- 1 October 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 54 (4) , 1076-1083
- https://doi.org/10.1073/pnas.54.4.1076
Abstract
Streptomycin (Sm)-resistant mutants have been isolated from a strain of Escherichia coli bearing a defective ornithine transcarbamylase phenotypically suppressible in the presence of Sm (OTCSSu)- Some of them remain competent and others become incompetent for the Sm-activated suppression of the OTCSSu defect. Within each class the imposition of further auxotrophic mutations yields strains that are competent for the Sm-activated suppression of some of these additional mutations. In vivo these strains have different responses to one type of genetic suppressor. Ribosomes isolated from these different strains have been shown to differ in their response to the misreading action of Sm.This publication has 11 references indexed in Scilit:
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