OBESITY AND FOOD REQUIREMENTS IN ALBINO MICE FOLLOWING ADMINISTRATION OF GOLDTHIOGLUCOSE

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Abstract
About 1/3 of stock albino mice that survived a single LD50 dose of goldthioglucose developed varying degrees of obesity. 6-12 mos. after injn. weights of 50-80 g. were commonly found in both sexes, and individual animals occasionally weighed over 90 g. The food intake of the animals that became obese exceeded that of controls both during periods of development and periods of maintenance of obesity. Injd. animals that did not become obese showed no increase in food consumption. The obese animals were able to mobilize their excess fat during starvation and could usually be starved down to their original wt.; they regained their prestarvation wt. on refeeding.

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