Origin of Pregnanetriol in a Patient with Adrenal Carcinoma

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Abstract
The metabolism of 17-hydroxyprogesterone-4-C14 was studied in a patient with metastatic adrenal carcinoma. The daily urine excretion of 119 mg of pregnane-3α,17,20α-triol by this patient was found to be derived principally from precursors other than 17-hydroxyprogesterone, such as 17-hydroxy-δ5-pregnenolone or its 20-keto reduction products. It was estimated that glandular secretion of 17-hydroxy-δ5-pregnenolone was between 154 mg and 2 g, with the true value nearer the latter figure. Evidence also was obtained for the hydroxylation of 17-hydroxyprogesterone-4-C14 at C-21 by the isolation of radioactive pregnane-3α,llβ,20,21-tetrols. The daily production of the urinary steroids is reported.

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