Effects on fluid balance induced by non-febrile intracerebroventricular infusions of PGE2, PGFZ2β, and arachidonic acid in the goat

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Abstract
Prostaglandins (PG) E2, F2.alpha. (30 ng/kg .cntdot. min-1) and arachidonic acid (150 and 300 ng/kg .cntdot. min-1) were infused for 30 min into the lateral cerebral ventricle of conscious hydrated and non-hydrated goats. As with PGE1, PGE2 inhibited the water diuresis, caused some increase in the renal Na excretion in the hydrated animal and elicited thirst in the non-hydrated goat. The effects of PGE2 were enhanced when hypertonic (0.25 M) NaCl was simultaneously infused into the ventricle. The antidiuretic effect of PGF2.alpha. was less pronounced, and drinking only occasionally occurred when this PG was infused into the non-hydrated animal. Only a weak, post-infusion reduction of the water diuresis was observed when arachidonic acid was administered into the hydrated goat. Neither the PG nor arachidonic acid affected the temperature regulation of the animals. The lack of febrile response possibly was due to the choice of Pt-Ir as material for the cerebral implantations. PGE2 might have interacted with CSF Na+ in stimulating juxtaventricular receptors involved in the control of fluid balance. PG of the E series apparently do not constitute a cerebral humoral link in pyrogen-induced fever.