CARCINOGENESIS OF 4-(HYDROXYMETHYL)BENZENEDIAZONIUM ION (TETRAFLUOROBORATE) OF AGARICUS-BISPORUS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 41  (6) , 2444-2449
Abstract
4-(Hydroxymethyl)benzenediazonium tetrafluoroborate was administered as 26 weekly s.c. injections of 50 .mu.g/g body wt to randomly bred Swiss mice. As a solvent control, sodium tetrafluoroborate was given as 26 weekly s.c. injections at 25 .mu.g/g body wt in 0.9% NaCl solution to another group of mice. The 4-(hydroxymethyl)benzenediazonium tetrafluoroborate treatment induced tumors in the subcutis and skin in incidences of 20 and 12%, respectively; while in the solvent sodium tetrafluoroborate-injected mice, the correspnding tumor incidences were 6 and 0%, respectively. Histopathologically, the tumors were classified as a fibroma, fibrosarcomas, rhabdomyosarcomas and an angiosarcoma in the subcutis and as squamous cell papillomas and carcinomas of the skin. 4-(Hydroxymethyl)benzenediazonium ion is an ingredient of the cultivated mushroom of commerce A. bisporus.