Prenatal diagnosis of a true mosaic trisomy 20 substantiated by demonstration of a gene dosage effect for adenosine deaminase (ADA)
- 1 March 1985
- journal article
- case report
- Published by Wiley in Prenatal Diagnosis
- Vol. 5 (2) , 163-166
- https://doi.org/10.1002/pd.1970050212
Abstract
Fibroblasts from a fetus with the prenatal diagnosis of mosaic trisomy 20 were cloned by dilution plating. Adenosine deaminase (ADA), a biochemical marker for chromosome 20, was assayed in trisomic clones and normal clones as control. The cytogenetic diagnosis was substantiated by demonstration of a triplex gene dosage effect for ADA in the trisomic cells.Keywords
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