Regional localization of the human genes for S-adenosylhomocysteine hydrolase (cen?q131) and adenosine deaminase (q131?qter) on chromosome 20
- 1 May 1984
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 66 (4) , 292-295
- https://doi.org/10.1007/bf00287630
Abstract
The gene loci for S-adenosylhomocysteine hydrolase (AHCY) and adenosine deaminase (ADA), two enzymes with related metabolic functions, have both been assigned to human chromosome 20. We have used rodent-human somatic hybrids containing translocations involving human chromosome 20 to more precisely determine the relative locations of the AHCY and ADA loci. Our results assign the AHCY locus to the long arm of chromosome 20, in the region cen→q131, and ADA to the region q131→qter.This publication has 27 references indexed in Scilit:
- Regional mapping of ADA and ITP on human chromosome 20: cytogenetic and somatic cell studies in an X/20 translocationCytogenetic and Genome Research, 1980
- Regional assignment of the ADA locus on 20q13.2→qter by gene dosage studiesCytogenetic and Genome Research, 1980
- Report of the committee on the genetic constitution of chromosomes 13, 14, 15, 16, 17, 18, 19, 20, 21, and 22Cytogenetic and Genome Research, 1979
- S -Adenosylhomocysteine Hydrolase Is an Adenosine-Binding Protein: a Target for Adenosine ToxicityScience, 1978
- Role of S-adenosylhomocysteine in adenosine-mediated toxicity in cultured mouse T lymphoma cellsCell, 1977
- Ouabain as a selective agent in the isolation of somatic cell hybridsCytogenetic and Genome Research, 1975
- Assignment of a Gene for Adenosine Deaminase to Human Chromosome 20Human Heredity, 1974
- ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITYThe Lancet, 1972
- Adenosine deaminase polymorphism in manAnnals of Human Genetics, 1968
- Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed RecombinantsScience, 1964