THE EFFECT OF ADMINISTRATION OF A SINGLE DOSE OF T-2 TOXIN ON BLOOD-COAGULATION IN THE RABBIT

  • 1 January 1982
    • journal article
    • research article
    • Vol. 46  (4) , 414-419
Abstract
The single i.v. administration of T-2 toxin to rabbits at 0.5 mg/kg body wt produced an alteration in several blood coagulation parameters. The activities of factors VII, VIII, IX, X and XI were decreased by .apprx. 40%, 6 h after T-2 toxin administration. Plasma fibrinogen concentration became elevated within 24 h after T-2 toxin exposure. Circulating platelet numbers were unaffected by T-2 toxin administration. The similarity of coagulation parameter changes induced by T-2 toxin in animals receiving daily s.c. injections of vitamin K (0.5 mg/kg body wt) and those in nonvitamin K-supplemented animals suggested that T-2 toxin did not function as a vitamin K antagonist.