CHARACTERIZATION OF LOW-DOSE INDUCED SUPPRESSOR CELLS IN ADJUVANT ARTHRITIS IN RATS

  • 1 January 1983
    • journal article
    • research article
    • Vol. 53  (1) , 60-66
Abstract
Characterization of suppressor cells in adjuvant arthritis was performed by using highly susceptible DA strain rats. Suppressor cells were induced after a single inoculation of a subarthritogenic dose of mycobacterial adjuvant. A relatively long incubation period was required for the induction of suppressor cells. Such cells were predominant in the draining lymph node and, after fractionation, only the sIg- [surface Ig-] population was effective in conferring unresponsiveness. In vivo irradiation or hydrocortisone treatment suggested that low dose induced suppressor cells were resistant to such immunosuppressive treatments. By using alkyldiamine as a non-mycobacterial arthritogenic adjuvant, it was suggested that unresponsiveness induced by low dose priming with mycobacterial adjuvant was antigen-specific.