The reduction of pantethine by an extract of camel intestine

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Abstract
The reduction of pantethine occurs by a coupling of 2 reactions. The 1st reaction is a non-enzymic exchange between pantethine and GSH to produce pantetheine and GSSG. The 2nd reaction involves a regeneration of GSH from GSSG by glutathione reductase. The pantethine-GSH exchange is dependent on alkaline pH, suggesting that the mercaptide ion, GS-, is the reactive species of GSH. Glutathione reductase has been partially purified from the intestinal mucosa of the camel. The enzyme is specific to GSSG and NADPH. Reversibility could not be demonstrated.