Humoral Antibodies in Sera of Patients with Bullous Skin Diseases

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Abstract
Summary Eleven sera of patients with bullous skin diseases were studied for antibodies to cell surface antigens by means of mixed-agglutinatioon tests with cell cultures. It was shown that seven sera contained IgG antibodies reacting with epithelial cell cultures but none of them had antibodies combining with fibroblastic cell cultures. The antibodies reacting with cell cultures were different from antibodies to intercellular antigens of epidermis detectable by immunofluorescent staining technique. Besides these antibodies, some sera of patients with bullous skin diseases were shown to contain IgM antibodies with anti-gamma globulin activity resembling the rheumatoid factor.