Antihypertensive and saluretic properties of the indoline and isoindoline series
- 1 January 1977
- journal article
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 5 (1) , 3-8
- https://doi.org/10.1185/03007997709110217
Abstract
The historical and molecular derivatives of thiazide and sulphonamide diuretics from 4-sulphonamido benzoic acid are briefly discussed. In a search for new antihypertensive agents many novel 3-sulphamoyl-4-chlorobenzamides in the indoline and iso-indoline series were synthesized. These compounds were screened in a battery of pharmacological tests and, in particular, their antihypertensive and diuretic activities were investigated in experimental hypertensive rats. The research programme resulted in the selection of indapamide as a compound which produced a significant and prolonged antihypertensive action with only a slight and transient diuresis.Keywords
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