Susceptibility to cleft palate and the major histocompatibility complex (H-2) in the mouse
- 1 April 1982
- journal article
- research article
- Published by Wiley in Teratology
- Vol. 25 (2) , 267-270
- https://doi.org/10.1002/tera.1420250216
Abstract
The congenic mouse strains B10 and B10.A differ genetically only at the H‐2 locus, B10 having the H‐2b and B10.A the H‐2a haplotype. The two strains also differ in susceptibility to cortisone‐induced cleft palate, B10 being more resistant than B10.A Since stage of palate closure is also associated with susceptibility to cortisone‐induced cleft palate it was postulated that the H‐2 haplotype may affect the cortisone‐induced cleft palate susceptibility by altering the stage of palate closure. The present study shows that palate closure occurs at the same stage in the two strains, so this hypothesis must be rejected.Keywords
This publication has 22 references indexed in Scilit:
- Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.Proceedings of the National Academy of Sciences, 1981
- A glucocorticoid receptor in fetal mouse: Its relationship to cleft palate formationTeratology, 1980
- Genetic and Environmental Factors in Cortisone Induced Cleft PalateExperimental Biology and Medicine, 1978
- Hepatic glucocorticoid receptors and the H–2 locusNature, 1978
- Effect of the H-2 gene complex rates of fibroblast intercellular adhesionThe Journal of cell biology, 1978
- Palatal cytosol cortisol-binding protein associated with cleft palate susceptibility and H–2 genotypeNature, 1977
- Cleft palate susceptibility linked to histocompatibility-2 (H-2) in the mouseImmunogenetics, 1975
- Influence of sex‐linked genes on embryonic sensitivity to cortisone in three strains of miceTeratology, 1973
- Evolutionary Significance of the HL-A SystemNature, 1972
- Genetic influences on induced cleft palate in different strains of miceThe Anatomical Record, 1963