HLA-DR3 and DR7 in coeliac disease: immunogenetic and clinical aspects.
- 1 August 1983
- Vol. 24 (8) , 706-712
- https://doi.org/10.1136/gut.24.8.706
Abstract
The association of HLA-A,B,C, DR polymorphisms and of Bf and GLO with coeliac disease was analysed in 100 Italian children. Primary involvement of HLA-DR3 and DR7 is apparent, while specificities of nearby loci are probably associated secondarily, because of linkage disequilibrium. Direct assessment of D/DR genotype through family studies and mixed lymphocyte cultures led to the recognition of two high risk genotypes DR3/3 and DR3/7, and of two lower risk genotypes DR3/X and DR7/X. The different weight of the HLA-dependent genetic factors is to some extent correlated with the clinical and immunological parameters, suggesting that the low-risk genotypes induce a milder expression of coeliac disease. Furthermore, other genetic factors, such as sex, appear to contribute to the penetrance of the disease, especially in the case of DR3/X and DR7/X.Keywords
This publication has 27 references indexed in Scilit:
- Histocompatibility Determinants in Israeli Jewish Patients with Coeliac Disease: Population and Family StudyTissue Antigens, 1981
- Gluten-sensitive EnteropathyJournal of Clinical Investigation, 1980
- HYDRALAZINE-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS: INFLUENCE OF HLA-DR AND SEX ON SUSCEPTIBILITYPublished by Elsevier ,1980
- Two HLA—D and DR Alleles are Associated with Coeliac DiseaseTissue Antigens, 1979
- HLA Haplotype Associations with DiseaseTissue Antigens, 1979
- HLA-DW3 ASSOCIATED WITH CŒLIAC DISEASEThe Lancet, 1976
- Predominance of histocompatibility antigen HL-A8 in patients with gluten-sensitive enteropathyJournal of Clinical Investigation, 1972
- EUROPEAN SOCIETY FOR PAEDIATRIC GASTROENTEROLOGYActa Paediatrica, 1970
- Immunochemical quantitation of antigens by single radial immunodiffusionImmunochemistry, 1965
- THE INHERITANCE OF COELIAC DISEASEAnnals of Human Genetics, 1959