"DAKLI": a multipurpose ligand with high affinity and selectivity for dynorphin (kappa opioid) binding sites.
- 1 October 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (19) , 7375-7379
- https://doi.org/10.1073/pnas.85.19.7375
Abstract
We describe a synthetic ligand, "DAKLI" (Dynorphin A-analogue Kappa LIgand), related to the opioid peptide dynorphin A A. A single reactive amino group at the extended carobxyl teminus permits various reporter groups to be attached, such as 125I-labeled Bolton-Hunter reagent, fluorescein isothiocyonate, or biotin. These derivatives have high affinity and selectivity for the dynorphin (.KAPPA. opioid) receptor. An incidental finding is that untreated guinea pig brain membranes have saturable avidin binding sites.This publication has 13 references indexed in Scilit:
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