Interleukin 6‐induced differentiation of a human B cell line into IgM‐secreting plasma cells is mediated by c‐fos
- 1 February 1992
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 22 (2) , 607-610
- https://doi.org/10.1002/eji.1830220248
Abstract
The role of the protooncogene c-fos in interleukin (IL) 6-induced B cell differentiation was assessed. Treatment of SKW 6.4 cells with IL 6 induced a transient and early stimulation of c-fos sense mRNA expression. The effect appeared within 30 min and returned to basal levels after 2 h. The addition of antisense oligonucleotides to c-fos significantly inhibited IL 6-induced IgM production by SKW 6.4 cells (p < 0.001), whereas control oligonucleotides had no inhibitory effect. These results indicate that activation of c-fos is involved in IL 6-induced differentiation of SKW 6.4 cells into IgM-secreting cells.Keywords
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