THE LIPID COMPOSITION AND WATER CONTENT OF CARCASS, SKELETAL MUSCLE, AND TESTICLE IN THE HOST COMPONENT OF THE ALBINO RAT – WALKER CARCINOMA 256 DUAL ORGANISM

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Abstract
The albino rat with an inoculated Walker carcinoma 256 was considered to be a dual organism and the influence of the tumor component upon the lipid and water concentration of the host component was studied. The total lipid, neutral fat, total fatty acids, total cholesterol, ester cholesterol, free cholesterol, and phospholipid, estimated by oxidative micromethods, and the water content were determined in carcass, skeletal muscle, and testicle of the host component after 28 days of growth of the tumor in 14 dual organisms and the data compared with corresponding values from 12 control albino rats without tumors. In the host component, the following statistically significant changes in concentration were found: a decrease in the neutral fat content of carcass and skeletal muscle and in the water content of the testicle; an increase in the phospholipid content of carcass and skeletal muscle, in the free cholesterol content of carcass, skeletal muscle, and testicle, in the ester cholesterol content of testicle and in the water content of carcass and skeletal muscle with corresponding changes in the concentration of total cholesterol, total fatty acids, and total lipid. In each instance, these shifts in concentration were toward the level in the tumor component, so that the lipid composition and water content of these tissues of the host component became more like those of the tumor component, suggesting a metabolism directing influence of the tumor upon the host.