Monoclonal opsonic mouse antibodies specific for streptococcal IgG Fc-receptor
- 1 November 1986
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 22 (3) , 251-256
- https://doi.org/10.1099/00222615-22-3-251
Abstract
Spleen cells from mice immunised with group-A type-M15 streptococci and boosted with purified IgG Fc-receptor (FcR) from this type were fused with Sp 2/0 mouse myeloma cells. The resulting hybridomas were screened by ELISA for antibody production. Two IgM-secreting cell lines were selected. The monoclonal antibodies and ascites fluids inhibited the binding of 125I-labelled human IgG and IgG Fc-fragments to group-A type-M15 streptococci. The monoclonal antibodies also displaced purified FcR towards the anode in electrophoresis. They opsonised group-A type M-15 streptococci for phagocytosis by human granulocytes in the presence of fresh human serum. It was concluded that FcR is important for group-A streptococcal virulence.This publication has 16 references indexed in Scilit:
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