Steigerung der Phagocytose von Peritonealmakrophagen durch Lysolecithin

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Abstract
Lysolecithin is formed in increased amounts in complement fixing immunoreactions. Increased lysolecithin formation can be demonstrated in the sera of man, guinea pigs, rats, rabbits and pigs. From this it is concluded that lysolecithin is an end product of the complement (C) reaction, and the question arises whether the lysolecithin so set free is of biological significance, e. g., as cytolysin. Lysolecithin at very low concentrations is highly surface active, so that in places of its formation, the activating or injurious effect on cell surfaces is to be considered. The action of very small concentrations of lysolecithin from peritoneal macrophages of the mouse in vitro and in vivo has been studied. Stuart and Cooper have reported the partly stimulating, partly inhibiting effect of lipoids (synthetic triglycerides) on the phagocytosis of macrophages. Under biological conditions in optimal phagocytosis antibodies and complement are involved. It is evident that phagocytosis is affected to a marked degree by the most minute amounts of lysolecithin.

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