Ultraviolet‐A induces activation of AP‐1 in cultured human keratinocytes
Open Access
- 8 April 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 384 (1) , 92-96
- https://doi.org/10.1016/0014-5793(96)00294-3
Abstract
UV‐A irradiation induces a time‐dependent activation of AP‐1 in NCTC 2544 human keratinocytes. 4 h after irradiation, a 2–3‐fold increase in AP‐1 activity is observed in human keratinocytes and fibroblasts. Activation is still detectable 24 h later. The UV‐A induced AP‐1 binding complex is shown to contain c‐Fos and c‐Jun proteins. Lipophilic vitamin E impedes UV‐A induced lipid peroxidation but does not prevent AP‐1 activation which is inhibited by N‐acetylcysteine, a hydrophilic antioxidant. This finding suggests that UV‐A‐dependent AP‐1 activation is sensitive to the cellular redox state but is not related to membrane lipid peroxidation.Keywords
This publication has 22 references indexed in Scilit:
- ACTIVATION OF NF‐KB IN HUMAN SKIN FIBROBLASTS BY THE OXIDATIVE STRESS GENERATED BY UVA RADIATIONPhotochemistry and Photobiology, 1995
- UV Radiation Protecting Efficacy of Cysteine Derivatives, Studies with UVA-induced Binding of 8-MOP and CPZ to Rat Epidermal Biomacromoleculesin VivoInternational Journal of Radiation Biology, 1995
- The epidermis: rising to the surfaceCurrent Opinion in Genetics & Development, 1994
- Ultraviolet A Decreases Epidermal Growth Factor (EGF) Processing in Cultured Human Fibroblasts and Keratinocytes: Inhibition of EGF-Induced Diacylglycerol FormationJournal of Investigative Dermatology, 1994
- EARLY ALTERATIONS OF ACTIN IN CULTURED HUMAN KERATINOCYTES AND FIBROBLASTS EXPOSED TO LONG‐WAVELENGTH RADIATIONS. POSSIBLE INVOLVEMENT IN THE UVA‐INDUCED PERTURBATIONS OF ENDOCYTOTIC PROCESSESPhotochemistry and Photobiology, 1994
- EXPOSURE TO LONG WAVELENGTH ULTRAVIOLET RADIATION DECREASES PROCESSING OF LOW DENSITY LIPOPROTEIN BY CULTURED HUMAN FIBROBLASTSPhotochemistry and Photobiology, 1993
- UVA-induced lipid peroxidation in cultured human fibroblastsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1991
- LONG WAVE ULTRAVIOLET RADIATION STIMULATES ARACHIDONIC ACID RELEASE AND CYCLOOXYGENASE ACTIVITY IN MAMMALIAN CELLS IN CULTUREPhotochemistry and Photobiology, 1989
- THE EFFECTS OF THE ULTRAVIOLET WAVELENGTHS OF RADIATION PRESENT IN SUNLIGHT ON HUMAN CELLS in vitroPhotochemistry and Photobiology, 1987
- ENDOGENOUS GLUTATHIONE PROTECTS HUMAN SKIN FIBROBLASTS AGAINST THE CYTOTOXIC ACTION OF UVB, UVA AND NEAR‐VISIBLE RADIATIONSPhotochemistry and Photobiology, 1986