Cimetidine and chlorpheniramine in the treatment of chronic idiopathic urticaria: a multi-centre randomized double-blind study
- 1 July 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 117 (1) , 81-88
- https://doi.org/10.1111/j.1365-2133.1987.tb04095.x
Abstract
One hundred and twenty patients with chronic idiopathic urticaria, who entered a study at five centres (Sheffield, London, Bristol, Cardiff and Leeds) were treated with therapeutic doses of the H1 antagonist chlorpheniramine for 6 weeks. Histamine 1 non‐rcsponders (40 patients) were entered into a double‐blind study and received chlorpheniramine plus cimetidine 400 mg q.d.s. (21 patients) or chlorpheniramine plus placebo (19 patients) for a further 8 weeks. The most important response measure was the change from baseline of the total symptom score: an assessment of the number and duration of new weals and degree of itching. There was a statistically significant difference between the average response in the two treatment groups in favour of chlorpheniramine plus cimetidine after 4 and 8 weeks' treatment (P<0.05 and P<0.01, respectively). No significant side‐effects related to treatment were noted.This publication has 4 references indexed in Scilit:
- The intra-epidermal epithelioma of Jadassohn: a distinct entityBritish Journal of Dermatology, 1979
- Cimetidine in chronic idiopathic urticaria: a randomized double-blind studyBritish Journal of Dermatology, 1978
- Treatment of chronic idiopathic urticaria with combined HI and H2 blockersClinical and Experimental Allergy, 1978
- HISTAMINE H2‐RECEPTORS IN THE HUMAN PERIPHERAL CIRCULATIONBritish Journal of Pharmacology, 1976