STUDY OF THE EXPRESSION OF A GLYCOPROTEIN OF RETROVIRAL ORIGIN IN THE PLASMA OF PATIENTS WITH HEMATOLOGIC DISORDERS AND IN THE PLASMA OF NORMAL INDIVIDUALS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 64  (4) , 832-841
Abstract
A 74,000 MW glycoprotein was purified from the plasma of a patient with chronic myelogenous leukemia in blast crisis. Monoclonal antibodies were produced in the mouse and used to characterize this protein. It was shown to contain p15E antigenic determinants and portions of a reverse transcriptase. The level of this protein was elevated in leukemic patients with high white blood cells counts and also in some patients with other hematopoietic disorders as compared to the level measured in normal individuals. The level of the protein was strongly reduced in acute leukemia patients after intense chemotherapy treatment. This protein is of endogenous retroviral origin and perhaps regulates hematopoietic tissues.

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