Protein phosphorylation in the brain
- 1 October 1983
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 305 (5935) , 583-588
- https://doi.org/10.1038/305583a0
Abstract
Protein phosphorylation represents an approach, sometimes the only approach available, to study the molecular basis for a wide variety of neurophysiological phenomena. The injection of protein kinases or protein kinase inhibitors into neurones has provided direct evidence that activation of protein kinases has an obligatory role in the mechanisms by which numerous extracellular signals produce specific physiological responses in neurones. A diversity of substrate proteins for the kinases have already been found. In several instances, the identity and functional role of these substrate proteins have been established.Keywords
This publication has 113 references indexed in Scilit:
- A calcium/calmodulin-dependent protein kinase from mammalian brain that phosphorylates Synapsin I: partial purification and characterizationJournal of Neuroscience, 1983
- Protein Kinase Injection Reduces Voltage-Dependent Potassium CurrentsScience, 1983
- Molecular Biology of Learning: Modulation of Transmitter ReleaseScience, 1982
- Ca2+ -activated K+ conductance in internally perfused snail neurons is enhanced by protein phosphorylation.Proceedings of the National Academy of Sciences, 1982
- Intracellular injection of protein kinase inhibitor blocks the serotonin-induced increase in K+ conductance in Aplysia neuron R15.Proceedings of the National Academy of Sciences, 1982
- Interaction of calmodulin with myosin light chain kinase and cAMP-dependent protein kinase in bovine brain.Published by Elsevier ,1981
- Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites.Proceedings of the National Academy of Sciences, 1981
- Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.Proceedings of the National Academy of Sciences, 1980
- Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell cultureProceedings of the National Academy of Sciences, 1980
- Phosphorylated Proteins as Physiological EffectorsScience, 1978