Effect of food on H2-receptor blockade in normal subjects and duodenal ulcer patients.
Open Access
- 1 February 1990
- Vol. 31 (2) , 148-150
- https://doi.org/10.1136/gut.31.2.148
Abstract
Two separate studies of 24 hour intragastric acidity were carried out in normal volunteers and duodenal ulcer patients to define the interaction of food and the antisecretory effects of H2-receptor blockers. Both investigations were double blind randomised comparisons using ranitidine 300 mg with either different meal times or ad libitum snacks after an evening meal. Meals taken after drug administration nearly abolished measurable antisectory effects. Median 24 hour pH was 1.3 on placebo, 2.6 when ranitidine was administered after the evening meal and 1.9 when administered before the evening meal. Snacks taken after evening dosing with ranitidine also significantly decreased pharmacodynamic efficacy. During placebo, median night-time pH was 1.3 without snacks and 1.4 with snacks. pH rose to 5.9 during ranitidine treatment when snacks were forbidden but was only 3.1 when snacks were allowed. These findings could be of therapeutic importance and should rationalise dietary advise to patients receiving H2 blockers. The timing of drug administration can be adjusted according to individual life styles.This publication has 8 references indexed in Scilit:
- Day-to-day variation of 24-hour intragastric acidityGastroenterology, 1988
- Continuous intravenous infusions of famotidine maintain high intragastric pH in duodenal ulcer.Gut, 1988
- Acid suppression in duodenal ulcer: a meta-analysis to define optimal dosing with antisecretory drugs.Gut, 1987
- Comparison of ranitidine 300 mg twice daily, 300 mg at night and placebo on 24‐hour intragastric acidity of duodenal ulcer patientsAlimentary Pharmacology & Therapeutics, 1987
- Single dose treatment with H2 receptor antagonists: is bedtime administration too late?Gut, 1987
- Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.Gut, 1983
- Reduction of Twenty-Four-Hour Gastric Acidity With Combination Drug Therapy in Patients with Duodenal UlcerGastroenterology, 1979