Targeting Mitochondria with Organelle‐Specific Compounds: Strategies and Applications
Top Cited Papers
- 12 August 2009
- journal article
- review article
- Published by Wiley in ChemBioChem
- Vol. 10 (12) , 1939-1950
- https://doi.org/10.1002/cbic.200900185
Abstract
Mitochondria are the energy factories of the cell and also serve as a checkpoint regulating programmed cell death. Not surprisingly, dysfunctional mitochondria are implicated in a variety of diseases ranging from metabolic disorders to cancer. Treatment of these diseases through the delivery of targeted drugs, however, is impeded by the difficulty of penetrating the membranes that define this organelle. The properties of this barrier serve as a major obstacle to drug delivery and a lack of effective transporters has hindered the advancement of mitochondrial medicine. Recently, however, synthetic transporters that show promise for the mito‐specific delivery of bioactive cargos have begun to emerge. This review summarizes the most exciting of these developments and discusses their applications.Keywords
This publication has 103 references indexed in Scilit:
- Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studiesBiochemistry (Moscow), 2008
- A Targetable Fluorescent Probe for Imaging Hydrogen Peroxide in the Mitochondria of Living CellsJournal of the American Chemical Society, 2008
- Activation of NO donors in mitochondria: Peroxidase metabolism of (2‐hydroxyamino‐vinyl)‐triphenyl‐phosphonium by cytochrome c releases NO and protects cells against apoptosisFEBS Letters, 2008
- Mitochondrial Medicine: Pharmacological targeting of mitochondria in diseaseBritish Journal of Pharmacology, 2007
- Interaction of the Mitochondria-targeted Antioxidant MitoQ with Phospholipid Bilayers and Ubiquinone OxidoreductasesJournal of Biological Chemistry, 2007
- Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neuronsBiomaterials, 2007
- Selective fluorescent imaging of superoxide in vivo using ethidium-based probesProceedings of the National Academy of Sciences, 2006
- Cerium and yttrium oxide nanoparticles are neuroprotectiveBiochemical and Biophysical Research Communications, 2006
- Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic NeuropathyScience, 1988
- Rhodamine 123 inhibits bioenergetic function in isolated rat liver mitochondriaBiochemical and Biophysical Research Communications, 1984