Protamines V. Synthesis of Three Fragments Spanning the Entire Sequence of [Perornithine]Thynnine Z1

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Abstract
An approach to the synthesis of protamines is based on the preparation of the corresponding perornithine analogs, in which all arginine residues are replaced by ornithines, followed by their conversion into arginine peptides by amidination. The general strategy for the synthesis, by conventional fragment condensation procedure, of thynnine Z1 and the synthesis of 3 suitably protected preornithine fragments, 1-12, 13-23 and 24-34, are reported.