.beta.-Adrenergic blocking agents with acute antihypertensive activity

Publisher Website
Google Scholar
Abstract
Modification of the pharmacological profile of the vasodilating/.beta.-adrenergic blocking agent 2-[4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-4-(trifluoromethyl)imidazole (1) was studied. Introduction of selected substituents onto the imidazole ring in place of the trifluoromethyl group yielded highly cardioselective .beta.-adrenergic blocking agents. The placement of alkyl or chloro groups onto the aryl ring of 1 produced a class of compounds characterized as antihypertensive .beta.-adrenergic blocking agents. In the examples, the acute antihypertensive activity does not appear to be due to vasodilating or .beta.2-agonist properties.