Effects of Vitamin D Metabolites and Analogues on Renal Function

Publisher Website
Google Scholar
Abstract
The long-term effects of vitamin D analogs and metabolites on renal function were assessed in 24 patients with and without chronic renal failure. Treatment for 5-45 mo. did not adversely affect renal function in 10 of 11 patients with stable renal function, although transient hypercalcemia did cause transient rises in plasma creatinine. Of 13 patients with progressive renal failure before treatment, vitamin D-like compounds or the vehicle used for their administration may have accelerated renal failure in 3 patients, independently of changes in plasma Ca or phosphate. Particular difficulties in assessing the effects of vitamin D-like compounds in progressive renal disease are discussed.