A Developmental Timing MicroRNA and Its Target Regulate Life Span in C. elegans
- 23 December 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5756) , 1954-1957
- https://doi.org/10.1126/science.1115596
Abstract
The microRNA lin-4 and its target, the putative transcription factor lin-14, control the timing of larval development in Caenorhabditis elegans. Here, we report that lin-4 and lin-14 also regulate life span in the adult. Reducing the activity of lin-4 shortened life span and accelerated tissue aging, whereas overexpressing lin-4 or reducing the activity of lin-14 extended life span. Lifespan extension conferred by a reduction in lin-14 was dependent on the DAF-16 and HSF-1 transcription factors, suggesting that the lin-4–lin-14 pair affects life span through the insulin/insulin-like growth factor–1 pathway. This work reveals a role for microRNAs and developmental timing genes in life-span regulation.Keywords
This publication has 30 references indexed in Scilit:
- Post‐embryonic expression ofC. elegansmicroRNAs belonging to thelin‐4andlet‐7families in the hypodermis and the reproductive systemDevelopmental Dynamics, 2005
- The Plasticity of Aging: Insights from Long-Lived MutantsCell, 2005
- A pancreatic islet-specific microRNA regulates insulin secretionNature, 2004
- MicroRNAsCell, 2004
- TEMPORAL PATTERN FORMATION BY HETEROCHRONIC GENESAnnual Review of Genetics, 1997
- daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegansScience, 1997
- daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegansScience, 1997
- A C. elegans mutant that lives twice as long as wild typeNature, 1993
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993
- The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switchNature, 1989