Studies on Human Leukemia. II. Structure and Quantitation of Myxovirus-Like Particles Associated With Human Leukemia23

Publisher Website
Google Scholar
Abstract
A method was developed (or the quantitation and examination of the morphology of myxovirus-like particles found in human leukemic and infectious mononucleosis materials. The average diameter of particles from leukemic patients was 178 mμ compared with 138 mμ for particles from patients with infectious mononucleosis. Particles from both sources were structurally similar to each other and to particles associated with avian and murine leukemia. However, no tail-like appendages were seen on particles from human specimens like those sometimes seen on particles associated with murine leukemias. Concentrations of over 3 × 1010 particles per ml were encountered in some human sera and plasmas. Normal whole blood cells, on prolonged storage at 4° C, released particles remarkably similar in size and morphology to the particles seen in materials from leukemic and infectious mononucleosis patients.