Gene UL11 of Herpes Simplex Virus Type 1 Encodes a Virion Protein which Is Myristylated
- 1 December 1989
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 70 (12) , 3147-3157
- https://doi.org/10.1099/0022-1317-70-12-3147
Abstract
Summary We have investigated whether herpes simplex virus (HSV) contains structural polypeptides which are modified by myristic acid. We demonstrate that herpes simplex virions contain a family of myristylated proteins, M r approximately 13 000 to 16 000. These were mapped, using HSV-1/HSV-2 intertypic recombinants, to 0.130 to 0.204 map units on the virus genome. Using anti-peptide sera, raised against the carboxyterminus of the predicted UL11 gene product, we have established that the myristylated virion polypeptides are products of the viral gene UL11.Keywords
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