Regional evaluation of the left ventricular wall motion by radionuclide ventriculography

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Abstract
ECG gated radionuclide ventriculography was performed in 85 patients with heart disease. From the analysis of time activity curves of each pixel, sets of parametric scans were displayed. Of 496 parametric scans, 192 were normal and 304 showed wall motion abnormalities. There was good correlation between the individual parametric scans (r .gtoreq. 0.815) and between parametric scans and contrast ventriculograms (r .gtoreq. 0.631) in the occurrence and extent of regional wall motion abnormalities. The highest sensitivity was revealed by the peak filling rate (relaxation velocity) scan. The best specificity was shown by scans using the amplitude and phase of the 1st Fourier element. Good results were obtained by a combination of 4 parametric images. The ability of the phase scan to detect local dyskinesis may be better than that of the contrast ventriculogram. Changes in parametric scans were related to, but preceded, impairment of left ventricular function (r .gtoreq. -0.513). Parametric scans provide a reliable, objective and non-invasive method for regional evaluation of left ventricular function, of great use in the diagnosis of local wall motion abnormalities and their effect on the heart performance.