Indomethacin prevents impaired perfusion of the dogs's brain after global ischemia.
- 1 November 1978
- journal article
- abstracts
- Published by Wolters Kluwer Health in Stroke
- Vol. 9 (6) , 591-594
- https://doi.org/10.1161/01.str.9.6.591
Abstract
Compression ischemia of the central nervous system (CNS) in heparinized dogs caused areas of diminished cerebral blood flow measured by 14C-antipyrine autoradiography. Intravenous infusion of indomethacin (1.5 or 4.0 mg/kg) approximately 1 hour before ischemia eliminated the circulatory defects. Prophylactic inhibition of prostaglandin synthetase may promote postischemic perfusion of the CNS by preventing vasoconstriction and by anti-hemostatic effects on blood.Keywords
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