A feasibility evaluation of an automated bloodcomponent collection system platelets and red cells

Publisher Website
Google Scholar
Abstract
BACKGROUND: The purpose of these studies was to evaluate the functional properties of blood components collected with an automated collection system. STUDY DESIGN AND METHODS: Single-donor platelets (n = 44) and packed red cell (RBC) units (n = 10) were collected. In vitro and in vivo assays were used to assess the function of single-donor platelet components stored for 5 days and of packed RBC units after storage for 42 days at 4°C. RESULTS: Adverse events observed in the 44 study subjects were minor. The mean 24-hour recovery value for the packed RBC units stored for 42 days was 83.6 ± 5.4 percent, with a mean percentage of hemolysis on Day 42 at 0.46 ± 0.19 percent. The 25 patients receiving platelet components achieved a mean corrected count increment of 15.1 ± 10.4 × 103. All platelet concentrates had less than 1 × 106 total white cells. CONCLUSION: Both in vitro and in vivo testing for the packed RBCs collected and stored for 42 days met the standards for both hemolysis and percentage of 51Cr 24-hour RBC recovery. The in vitro results and transfusion data on white cell-reduced platelet components transfused to thrombocytopenic patients were comparable to those on available platelet components.